| Segunda Division | 1 | 2005-08-28 | HOME | CD Castellon | 1-0 |
| Segunda Division | 2 | 2005-09-04 | AWAY | Polideportivo Ejido | 2-1 |
| Segunda Division | 3 | 2005-09-10 | HOME | Numancia CD | 5-0 |
| Segunda Division | 4 | 2005-09-18 | AWAY | Racing Ferrol | 0-0 |
| Segunda Division | 5 | 2005-09-24 | HOME | Xerez | 0-1 |
| Segunda Division | 6 | 2005-10-02 | AWAY | FC Elche | 3-2 |
| Segunda Division | 7 | 2005-10-08 | HOME | Hercules Alicante CF | 0-1 |
| Segunda Division | 8 | 2005-10-16 | AWAY | Real Murcia | 2-0 |
| Segunda Division | 9 | 2005-10-23 | HOME | Ciudad de Murcia | 1-2 |
| Segunda Division | 10 | 2005-10-30 | AWAY | Albacete Palomie | 1-0 |
| Segunda Division | 11 | 2005-11-05 | HOME | CD Tenerife | 2-1 |
| Segunda Division | 12 | 2005-11-12 | AWAY | Club Gimnastic de Tarragona | 0-2 |
| Segunda Division | 13 | 2005-11-19 | HOME | Sporting Gijon | 0-1 |
| Segunda Division | 14 | 2005-11-27 | AWAY | Recreativo de Huelva | 3-2 |
| Segunda Division | 15 | 2005-12-03 | HOME | Real Valladolid | 0-4 |
| Segunda Division | 16 | 2005-12-12 | AWAY | Atletico Malagueno | 0-1 |
| Segunda Division | 17 | 2005-12-17 | HOME | SD Eibar | 0-0 |
| Segunda Division | 18 | 2005-12-20 | AWAY | Real Madrid Castilla | 0-0 |
| Segunda Division | 19 | 2006-01-08 | HOME | Lorca Deportiva | 2-2 |
| Segunda Division | 20 | 2006-01-15 | HOME | UD Almeria | 1-0 |
| Segunda Division | 21 | 2006-01-21 | AWAY | Levante UD | 2-0 |
| Segunda Division | 22 | 2006-01-29 | AWAY | CD Castellon | 0-3 |
| Segunda Division | 23 | 2006-02-05 | HOME | Polideportivo Ejido | 1-0 |
| Segunda Division | 24 | 2006-02-12 | AWAY | Numancia CD | 1-0 |
| Segunda Division | 25 | 2006-02-19 | HOME | Racing Ferrol | 1-1 |
| Segunda Division | 26 | 2006-02-26 | AWAY | Xerez | 0-1 |
| Segunda Division | 27 | 2006-03-04 | HOME | FC Elche | 0-0 |
| Segunda Division | 28 | 2006-03-11 | AWAY | Hercules Alicante CF | 2-1 |
| Segunda Division | 29 | 2006-03-18 | HOME | Real Murcia | 1-1 |
| Segunda Division | 30 | 2006-03-25 | AWAY | Ciudad de Murcia | 3-1 |
| Segunda Division | 31 | 2006-04-02 | HOME | Albacete Palomie | 3-0 |
| Segunda Division | 32 | 2006-04-09 | AWAY | CD Tenerife | 2-2 |
| Segunda Division | 33 | 2006-04-15 | HOME | Club Gimnastic de Tarragona | 1-2 |
| Segunda Division | 34 | 2006-04-23 | AWAY | Sporting Gijon | 2-0 |
| Segunda Division | 35 | 2006-04-30 | HOME | Recreativo de Huelva | 0-4 |
| Segunda Division | 36 | 2006-05-07 | AWAY | Real Valladolid | 3-2 |
| Segunda Division | 37 | 2006-05-14 | HOME | Atletico Malagueno | 0-0 |
| Segunda Division | 38 | 2006-05-20 | AWAY | SD Eibar | 1-1 |
| Segunda Division | 39 | 2006-05-28 | HOME | Real Madrid Castilla | 2-1 |
| Segunda Division | 40 | 2006-06-04 | AWAY | Lorca Deportiva | 1-2 |
| Segunda Division | 41 | 2006-06-11 | AWAY | UD Almeria | 3-1 |
| Segunda Division | 42 | 2006-06-17 | HOME | Levante UD | 0-1 |
