| Primera Division | 1 | 2015-08-23 | HOME | Real Madrid | 0-0 |
| Primera Division | 2 | 2015-08-29 | AWAY | Real Sociedad | 0-0 |
| Primera Division | 3 | 2015-09-12 | HOME | Valencia CF | 0-1 |
| Primera Division | 4 | 2015-09-20 | AWAY | Deportivo la Coruna | 2-3 |
| Primera Division | 5 | 2015-09-23 | AWAY | Rayo Vallecano | 2-1 |
| Primera Division | 6 | 2015-09-27 | HOME | Real Betis Sevilla | 1-2 |
| Primera Division | 7 | 2015-10-03 | AWAY | Espanyol Barcelona | 1-2 |
| Primera Division | 8 | 2015-10-19 | HOME | FC Granada | 3-3 |
| Primera Division | 9 | 2015-10-26 | AWAY | Athletic de Bilbao | 3-0 |
| Primera Division | 10 | 2015-11-01 | HOME | Malaga CF | 1-0 |
| Primera Division | 11 | 2015-11-08 | AWAY | Atletico de Madrid | 1-0 |
| Primera Division | 12 | 2015-11-22 | HOME | Levante UD | 0-3 |
| Primera Division | 13 | 2015-11-28 | AWAY | Celta Vigo | 2-1 |
| Primera Division | 14 | 2015-12-06 | HOME | Las Palmas | 3-1 |
| Primera Division | 15 | 2015-12-12 | AWAY | Sevilla FC | 2-0 |
| Primera Division | 17 | 2015-12-30 | AWAY | SD Eibar | 2-0 |
| Primera Division | 18 | 2016-01-04 | HOME | Getafe CF | 1-2 |
| Primera Division | 19 | 2016-01-10 | AWAY | Villarreal CF | 2-0 |
| Primera Division | 20 | 2016-01-17 | AWAY | Real Madrid | 5-1 |
| Primera Division | 21 | 2016-01-22 | HOME | Real Sociedad | 5-1 |
| Primera Division | 22 | 2016-01-31 | AWAY | Valencia CF | 0-1 |
| Primera Division | 23 | 2016-02-06 | HOME | Deportivo la Coruna | 1-1 |
| Primera Division | 24 | 2016-02-12 | HOME | Rayo Vallecano | 2-2 |
| Primera Division | 16 | 2016-02-17 | HOME | FC Barcelona | 1-3 |
| Primera Division | 25 | 2016-02-20 | AWAY | Real Betis Sevilla | 1-1 |
| Primera Division | 26 | 2016-02-27 | HOME | Espanyol Barcelona | 2-4 |
| Primera Division | 27 | 2016-03-03 | AWAY | FC Granada | 2-0 |
| Primera Division | 28 | 2016-03-06 | HOME | Athletic de Bilbao | 0-2 |
| Primera Division | 29 | 2016-03-11 | AWAY | Malaga CF | |
| Primera Division | 30 | 2016-03-19 | HOME | Atletico de Madrid | |
| Primera Division | 31 | 2016-04-04 | AWAY | Levante UD | |
| Primera Division | 32 | 2016-04-10 | HOME | Celta Vigo | |
| Primera Division | 33 | 2016-04-17 | AWAY | Las Palmas | |
| Primera Division | 34 | 2016-04-20 | HOME | Sevilla FC | |
| Primera Division | 35 | 2016-04-24 | AWAY | FC Barcelona | |
| Primera Division | 36 | 2016-05-01 | HOME | SD Eibar | |
| Primera Division | 37 | 2016-05-08 | AWAY | Getafe CF | |
| Primera Division | 38 | 2016-05-15 | HOME | Villarreal CF |
