| Primera Division | 1 | 2015-08-22 | AWAY | Atletico de Madrid | 1-0 |
| Primera Division | 2 | 2015-08-30 | HOME | Levante UD | 0-0 |
| Primera Division | 3 | 2015-09-13 | AWAY | Celta Vigo | 3-3 |
| Primera Division | 4 | 2015-09-20 | HOME | Rayo Vallecano | 0-1 |
| Primera Division | 5 | 2015-09-23 | HOME | Sevilla FC | 2-0 |
| Primera Division | 6 | 2015-09-26 | AWAY | FC Barcelona | 2-1 |
| Primera Division | 7 | 2015-10-03 | HOME | SD Eibar | 0-2 |
| Primera Division | 8 | 2015-10-18 | AWAY | Getafe CF | 4-0 |
| Primera Division | 9 | 2015-10-25 | HOME | Villarreal CF | 0-0 |
| Primera Division | 10 | 2015-10-31 | AWAY | Real Madrid | 3-1 |
| Primera Division | 11 | 2015-11-06 | HOME | Real Sociedad | 2-0 |
| Primera Division | 12 | 2015-11-21 | AWAY | Valencia CF | 1-1 |
| Primera Division | 13 | 2015-11-28 | HOME | Deportivo la Coruna | 0-2 |
| Primera Division | 14 | 2015-12-06 | AWAY | Sporting Gijon | 3-1 |
| Primera Division | 15 | 2015-12-12 | HOME | Real Betis Sevilla | 1-0 |
| Primera Division | 16 | 2015-12-19 | AWAY | Espanyol Barcelona | 1-0 |
| Primera Division | 17 | 2015-12-30 | HOME | FC Granada | 4-1 |
| Primera Division | 18 | 2016-01-03 | AWAY | Athletic de Bilbao | 2-2 |
| Primera Division | 19 | 2016-01-10 | HOME | Malaga CF | 1-1 |
| Primera Division | 20 | 2016-01-17 | HOME | Atletico de Madrid | 0-3 |
| Primera Division | 21 | 2016-01-25 | AWAY | Levante UD | 3-2 |
| Primera Division | 22 | 2016-01-31 | HOME | Celta Vigo | 2-1 |
| Primera Division | 23 | 2016-02-06 | AWAY | Rayo Vallecano | 2-0 |
| Primera Division | 24 | 2016-02-14 | AWAY | Sevilla FC | 2-0 |
| Primera Division | 25 | 2016-02-20 | HOME | FC Barcelona | 1-2 |
| Primera Division | 26 | 2016-02-26 | AWAY | SD Eibar | 0-1 |
| Primera Division | 27 | 2016-03-01 | HOME | Getafe CF | 4-0 |
| Primera Division | 28 | 2016-03-05 | AWAY | Villarreal CF | 0-1 |
| Primera Division | 29 | 2016-03-13 | HOME | Real Madrid | |
| Primera Division | 30 | 2016-03-19 | AWAY | Real Sociedad | |
| Primera Division | 31 | 2016-04-02 | HOME | Valencia CF | |
| Primera Division | 32 | 2016-04-10 | AWAY | Deportivo la Coruna | |
| Primera Division | 33 | 2016-04-17 | HOME | Sporting Gijon | |
| Primera Division | 34 | 2016-04-20 | AWAY | Real Betis Sevilla | |
| Primera Division | 35 | 2016-04-24 | HOME | Espanyol Barcelona | |
| Primera Division | 36 | 2016-05-01 | AWAY | FC Granada | |
| Primera Division | 37 | 2016-05-08 | HOME | Athletic de Bilbao | |
| Primera Division | 38 | 2016-05-15 | AWAY | Malaga CF |
