| Segunda Division | 1 | 2010-08-29 | HOME | Cordoba | 1-1 |
| Segunda Division | 2 | 2010-09-05 | AWAY | CD Tenerife | 1-2 |
| Segunda Division | 3 | 2010-09-10 | HOME | Club Gimnastic de Tarragona | 1-0 |
| Segunda Division | 4 | 2010-09-18 | AWAY | SD Huesca | 0-1 |
| Segunda Division | 5 | 2010-09-26 | HOME | AD Alcorcon | 1-1 |
| Segunda Division | 6 | 2010-10-01 | AWAY | Villarreal CF B | 0-1 |
| Segunda Division | 7 | 2010-10-10 | HOME | FC Granada | 1-2 |
| Segunda Division | 8 | 2010-10-15 | AWAY | Recreativo de Huelva | 0-2 |
| Segunda Division | 9 | 2010-10-24 | HOME | Real Betis Sevilla | 0-3 |
| Segunda Division | 10 | 2010-10-30 | AWAY | Real Valladolid | 1-0 |
| Segunda Division | 11 | 2010-11-06 | HOME | Albacete Palomie | 1-0 |
| Segunda Division | 12 | 2010-11-14 | AWAY | SD Ponferradina | 3-2 |
| Segunda Division | 13 | 2010-11-20 | HOME | Las Palmas | 4-2 |
| Segunda Division | 14 | 2010-11-27 | AWAY | Girona FC | 1-1 |
| Segunda Division | 15 | 2010-12-05 | AWAY | FC Elche | 3-1 |
| Segunda Division | 16 | 2010-12-12 | HOME | Rayo Vallecano | 0-1 |
| Segunda Division | 17 | 2010-12-18 | AWAY | Celta Vigo | 1-0 |
| Segunda Division | 18 | 2011-01-03 | HOME | Xerez | 2-3 |
| Segunda Division | 19 | 2011-01-08 | AWAY | FC Cartagena | 1-0 |
| Segunda Division | 20 | 2011-01-15 | HOME | FC Barcelona B | 2-3 |
| Segunda Division | 21 | 2011-01-23 | AWAY | Numancia CD | 3-2 |
| Segunda Division | 22 | 2011-01-29 | AWAY | Cordoba | 2-0 |
| Segunda Division | 23 | 2011-02-05 | HOME | CD Tenerife | 1-2 |
| Segunda Division | 24 | 2011-02-13 | AWAY | Club Gimnastic de Tarragona | 2-0 |
| Segunda Division | 25 | 2011-02-19 | HOME | SD Huesca | 1-1 |
| Segunda Division | 26 | 2011-02-26 | AWAY | AD Alcorcon | 4-0 |
| Segunda Division | 27 | 2011-03-01 | HOME | Villarreal CF B | 1-0 |
| Segunda Division | 28 | 2011-03-05 | AWAY | FC Granada | 0-1 |
| Segunda Division | 29 | 2011-03-13 | HOME | Recreativo de Huelva | 0-1 |
| Segunda Division | 30 | 2011-03-19 | AWAY | Real Betis Sevilla | 1-0 |
| Segunda Division | 31 | 2011-03-27 | HOME | Real Valladolid | 0-5 |
| Segunda Division | 32 | 2011-04-02 | AWAY | Albacete Palomie | 1-0 |
| Segunda Division | 33 | 2011-04-10 | HOME | SD Ponferradina | 2-2 |
| Segunda Division | 34 | 2011-04-16 | AWAY | Las Palmas | 2-1 |
| Segunda Division | 35 | 2011-04-22 | HOME | Girona FC | 1-0 |
| Segunda Division | 36 | 2011-04-30 | HOME | FC Elche | 5-4 |
| Segunda Division | 37 | 2011-05-07 | AWAY | Rayo Vallecano | 1-2 |
| Segunda Division | 38 | 2011-05-12 | HOME | Celta Vigo | 1-1 |
| Segunda Division | 39 | 2011-05-15 | AWAY | Xerez | 2-0 |
| Segunda Division | 40 | 2011-05-21 | HOME | FC Cartagena | 2-0 |
| Segunda Division | 41 | 2011-05-29 | AWAY | FC Barcelona B | 5-1 |
| Segunda Division | 42 | 2011-06-04 | HOME | Numancia CD | 2-2 |
