| Primera Division | 1 | 1980-09-07 | HOME | Real Madrid | 1-2 |
| Primera Division | 2 | 1980-09-14 | AWAY | Real Valladolid | 0-0 |
| Primera Division | 3 | 1980-09-21 | AWAY | Atletico de Madrid | 2-1 |
| Primera Division | 4 | 1980-09-28 | HOME | Athletic de Bilbao | 1-1 |
| Primera Division | 5 | 1980-10-05 | AWAY | Sevilla FC | 1-0 |
| Primera Division | 6 | 1980-10-12 | HOME | Real Murcia | 0-0 |
| Primera Division | 7 | 1980-10-19 | AWAY | Espanyol Barcelona | 1-0 |
| Primera Division | 8 | 1980-10-26 | HOME | Sporting Gijon | 1-1 |
| Primera Division | 9 | 1980-11-01 | AWAY | Valencia CF | 3-1 |
| Primera Division | 10 | 1980-11-09 | HOME | Osasuna | 1-1 |
| Primera Division | 11 | 1980-11-15 | AWAY | Las Palmas | 3-0 |
| Primera Division | 12 | 1980-11-23 | HOME | Real Sociedad | 3-2 |
| Primera Division | 13 | 1980-11-30 | AWAY | Real Betis Sevilla | 2-0 |
| Primera Division | 14 | 1980-12-07 | HOME | Hercules Alicante CF | 0-3 |
| Primera Division | 15 | 1980-12-13 | AWAY | FC Barcelona | 6-0 |
| Primera Division | 16 | 1980-12-21 | HOME | FC Salamanca | 3-2 |
| Primera Division | 17 | 1980-12-28 | AWAY | Real Zaragoza | 1-0 |
| Primera Division | 18 | 1981-01-04 | AWAY | Real Madrid | 4-0 |
| Primera Division | 19 | 1981-01-11 | HOME | Real Valladolid | 1-1 |
| Primera Division | 20 | 1981-01-18 | HOME | Atletico de Madrid | 2-1 |
| Primera Division | 21 | 1981-01-25 | AWAY | Athletic de Bilbao | 5-1 |
| Primera Division | 22 | 1981-02-01 | HOME | Sevilla FC | 0-0 |
| Primera Division | 23 | 1981-02-08 | AWAY | Real Murcia | 2-1 |
| Primera Division | 24 | 1981-02-15 | HOME | Espanyol Barcelona | 2-0 |
| Primera Division | 25 | 1981-02-22 | AWAY | Sporting Gijon | 5-2 |
| Primera Division | 26 | 1981-03-01 | HOME | Valencia CF | 1-0 |
| Primera Division | 27 | 1981-03-08 | AWAY | Osasuna | 2-1 |
| Primera Division | 28 | 1981-03-15 | HOME | Las Palmas | 0-1 |
| Primera Division | 29 | 1981-03-22 | AWAY | Real Sociedad | 3-1 |
| Primera Division | 30 | 1981-03-29 | HOME | Real Betis Sevilla | 0-2 |
| Primera Division | 31 | 1981-04-05 | AWAY | Hercules Alicante CF | 1-0 |
| Primera Division | 32 | 1981-04-12 | HOME | FC Barcelona | 2-5 |
| Primera Division | 33 | 1981-04-19 | AWAY | FC Salamanca | 2-1 |
| Primera Division | 34 | 1981-04-26 | HOME | Real Zaragoza | 3-1 |
