| Segunda Division | 1 | 2015-08-23 | HOME | Albacete Palomie | 2-2 |
| Segunda Division | 2 | 2015-08-30 | AWAY | CD Tenerife | 1-2 |
| Segunda Division | 3 | 2015-09-05 | HOME | Girona FC | 1-0 |
| Segunda Division | 4 | 2015-09-12 | AWAY | FC Elche | 1-0 |
| Segunda Division | 5 | 2015-09-20 | HOME | RCD Mallorca | 1-0 |
| Segunda Division | 6 | 2015-09-27 | AWAY | Real Valladolid | 0-0 |
| Segunda Division | 7 | 2015-10-03 | HOME | AD Alcorcon | 0-2 |
| Segunda Division | 8 | 2015-10-10 | AWAY | SD Ponferradina | 2-2 |
| Segunda Division | 9 | 2015-10-17 | HOME | Athletic Bilbao B | 2-1 |
| Segunda Division | 10 | 2015-10-25 | AWAY | Numancia CD | 1-1 |
| Segunda Division | 11 | 2015-10-31 | AWAY | Cordoba | 2-0 |
| Segunda Division | 12 | 2015-11-08 | HOME | SD Huesca | 2-0 |
| Segunda Division | 13 | 2015-11-15 | AWAY | Real Oviedo | 2-0 |
| Segunda Division | 14 | 2015-11-22 | HOME | UE Llagostera | 2-0 |
| Segunda Division | 15 | 2015-11-29 | AWAY | CD Mirandes | 0-1 |
| Segunda Division | 16 | 2015-12-05 | HOME | UD Almeria | 2-2 |
| Segunda Division | 17 | 2015-12-13 | AWAY | CD Leganes | 1-0 |
| Segunda Division | 18 | 2015-12-19 | HOME | Real Zaragoza | 3-1 |
| Segunda Division | 19 | 2016-01-02 | AWAY | Osasuna | 1-1 |
| Segunda Division | 20 | 2016-01-09 | HOME | CD Lugo | 1-2 |
| Segunda Division | 21 | 2016-01-17 | AWAY | Deportivo Alaves | 1-3 |
| Segunda Division | 22 | 2016-01-24 | AWAY | Albacete Palomie | 1-1 |
| Segunda Division | 23 | 2016-01-31 | HOME | CD Tenerife | 2-1 |
| Segunda Division | 24 | 2016-02-07 | AWAY | Girona FC | 1-1 |
| Segunda Division | 25 | 2016-02-13 | HOME | FC Elche | 1-0 |
| Segunda Division | 26 | 2016-02-20 | AWAY | RCD Mallorca | 2-2 |
| Segunda Division | 27 | 2016-02-28 | HOME | Real Valladolid | 1-1 |
| Segunda Division | 28 | 2016-03-06 | AWAY | AD Alcorcon | 1-1 |
| Segunda Division | 29 | 2016-03-13 | HOME | SD Ponferradina | |
| Segunda Division | 30 | 2016-03-20 | AWAY | Athletic Bilbao B | |
| Segunda Division | 31 | 2016-03-26 | HOME | Numancia CD | |
| Segunda Division | 32 | 2016-04-03 | HOME | Cordoba | |
| Segunda Division | 33 | 2016-04-10 | AWAY | SD Huesca | |
| Segunda Division | 34 | 2016-04-17 | HOME | Real Oviedo | |
| Segunda Division | 35 | 2016-04-24 | AWAY | UE Llagostera | |
| Segunda Division | 36 | 2016-05-01 | HOME | CD Mirandes | |
| Segunda Division | 37 | 2016-05-08 | AWAY | UD Almeria | |
| Segunda Division | 38 | 2016-05-11 | HOME | CD Leganes | |
| Segunda Division | 39 | 2016-05-15 | AWAY | Real Zaragoza | |
| Segunda Division | 40 | 2016-05-22 | HOME | Osasuna | |
| Segunda Division | 41 | 2016-05-29 | AWAY | CD Lugo | |
| Segunda Division | 42 | 2016-06-05 | HOME | Deportivo Alaves |
