| Eredivisie | 1 | 2015-08-11 | HOME | De Graafschap Doetinchem | 3-1 |
| Eredivisie | 2 | 2015-08-16 | AWAY | FC Utrecht | 1-1 |
| Eredivisie | 3 | 2015-08-22 | HOME | PSV Eindhoven | 1-1 |
| Eredivisie | 4 | 2015-08-29 | HOME | FC Zwolle | 1-1 |
| Eredivisie | 5 | 2015-09-13 | AWAY | FC Groningen | 3-1 |
| Eredivisie | 6 | 2015-09-18 | AWAY | NEC Nijmegen | 2-0 |
| Eredivisie | 7 | 2015-09-26 | HOME | Vitesse Arnheim | 0-0 |
| Eredivisie | 8 | 2015-10-02 | AWAY | Heracles Almelo | 2-0 |
| Eredivisie | 9 | 2015-10-18 | HOME | Feyenoord Rotterdam | 2-5 |
| Eredivisie | 10 | 2015-10-24 | AWAY | Willem II Tilburg | 2-2 |
| Eredivisie | 11 | 2015-11-01 | HOME | Cambuur Leeuwarden | 2-0 |
| Eredivisie | 12 | 2015-11-07 | AWAY | Twente Enschede | 1-4 |
| Eredivisie | 13 | 2015-11-21 | AWAY | AZ Alkmaar | 3-1 |
| Eredivisie | 14 | 2015-11-28 | HOME | Roda JC Kerkrade | 3-0 |
| Eredivisie | 15 | 2015-12-05 | AWAY | Ajax Amsterdam | 5-2 |
| Eredivisie | 16 | 2015-12-11 | HOME | Excelsior Rotterdam | 2-1 |
| Eredivisie | 17 | 2015-12-20 | HOME | Den Haag ADO | 0-4 |
| Eredivisie | 18 | 2016-01-16 | AWAY | FC Zwolle | 5-2 |
| Eredivisie | 19 | 2016-01-23 | HOME | Willem II Tilburg | 3-1 |
| Eredivisie | 20 | 2016-01-28 | AWAY | Feyenoord Rotterdam | 1-2 |
| Eredivisie | 21 | 2016-01-31 | AWAY | Cambuur Leeuwarden | 0-1 |
| Eredivisie | 22 | 2016-02-06 | HOME | Twente Enschede | 1-3 |
| Eredivisie | 23 | 2016-02-13 | AWAY | Vitesse Arnheim | 3-0 |
| Eredivisie | 24 | 2016-02-20 | HOME | NEC Nijmegen | 1-1 |
| Eredivisie | 25 | 2016-02-28 | AWAY | De Graafschap Doetinchem | 0-1 |
| Eredivisie | 26 | 2016-03-05 | HOME | FC Utrecht | 0-4 |
| Eredivisie | 27 | 2016-03-12 | AWAY | PSV Eindhoven | |
| Eredivisie | 28 | 2016-03-19 | HOME | Heracles Almelo | |
| Eredivisie | 29 | 2016-04-03 | AWAY | Roda JC Kerkrade | |
| Eredivisie | 30 | 2016-04-10 | HOME | AZ Alkmaar | |
| Eredivisie | 31 | 2016-04-17 | AWAY | Excelsior Rotterdam | |
| Eredivisie | 32 | 2016-04-20 | HOME | Ajax Amsterdam | |
| Eredivisie | 33 | 2016-05-01 | HOME | FC Groningen | |
| Eredivisie | 34 | 2016-05-08 | AWAY | Den Haag ADO |
