| Eredivisie | 1 | 2015-08-12 | HOME | Twente Enschede | 1-1 |
| Eredivisie | 2 | 2015-08-16 | AWAY | PSV Eindhoven | 2-0 |
| Eredivisie | 3 | 2015-08-21 | HOME | Excelsior Rotterdam | 2-0 |
| Eredivisie | 4 | 2015-08-29 | AWAY | FC Utrecht | 2-0 |
| Eredivisie | 5 | 2015-09-13 | HOME | SC Heerenveen | 3-1 |
| Eredivisie | 6 | 2015-09-20 | HOME | AZ Alkmaar | 2-0 |
| Eredivisie | 7 | 2015-09-26 | AWAY | Ajax Amsterdam | 2-0 |
| Eredivisie | 8 | 2015-10-04 | AWAY | Vitesse Arnheim | 5-0 |
| Eredivisie | 9 | 2015-10-17 | HOME | Willem II Tilburg | 2-1 |
| Eredivisie | 10 | 2015-10-25 | AWAY | NEC Nijmegen | 1-1 |
| Eredivisie | 11 | 2015-10-31 | HOME | FC Zwolle | 2-0 |
| Eredivisie | 12 | 2015-11-08 | AWAY | Cambuur Leeuwarden | 2-2 |
| Eredivisie | 13 | 2015-11-21 | AWAY | De Graafschap Doetinchem | 1-2 |
| Eredivisie | 14 | 2015-11-29 | HOME | Den Haag ADO | 2-1 |
| Eredivisie | 15 | 2015-12-06 | AWAY | Roda JC Kerkrade | 0-0 |
| Eredivisie | 16 | 2015-12-13 | HOME | Feyenoord Rotterdam | 1-1 |
| Eredivisie | 17 | 2015-12-19 | AWAY | Heracles Almelo | 2-1 |
| Eredivisie | 18 | 2016-01-17 | HOME | FC Utrecht | 1-4 |
| Eredivisie | 19 | 2016-01-22 | HOME | NEC Nijmegen | 0-0 |
| Eredivisie | 20 | 2016-01-26 | AWAY | Willem II Tilburg | 1-1 |
| Eredivisie | 21 | 2016-01-30 | AWAY | FC Zwolle | 1-3 |
| Eredivisie | 22 | 2016-02-07 | HOME | Cambuur Leeuwarden | 2-0 |
| Eredivisie | 23 | 2016-02-14 | HOME | Ajax Amsterdam | 1-2 |
| Eredivisie | 24 | 2016-02-20 | AWAY | AZ Alkmaar | 4-1 |
| Eredivisie | 25 | 2016-02-27 | AWAY | Twente Enschede | 2-0 |
| Eredivisie | 26 | 2016-03-05 | HOME | PSV Eindhoven | 0-3 |
| Eredivisie | 27 | 2016-03-12 | AWAY | Excelsior Rotterdam | |
| Eredivisie | 28 | 2016-03-20 | HOME | Vitesse Arnheim | |
| Eredivisie | 29 | 2016-04-03 | AWAY | Den Haag ADO | |
| Eredivisie | 30 | 2016-04-10 | HOME | De Graafschap Doetinchem | |
| Eredivisie | 31 | 2016-04-16 | AWAY | Feyenoord Rotterdam | |
| Eredivisie | 32 | 2016-04-19 | HOME | Roda JC Kerkrade | |
| Eredivisie | 33 | 2016-05-01 | AWAY | SC Heerenveen | |
| Eredivisie | 34 | 2016-05-08 | HOME | Heracles Almelo |
