| Eredivisie | 1 | 2015-08-11 | HOME | PSV Eindhoven | 2-2 |
| Eredivisie | 2 | 2015-08-15 | AWAY | Twente Enschede | 1-4 |
| Eredivisie | 3 | 2015-08-23 | HOME | FC Utrecht | 1-1 |
| Eredivisie | 4 | 2015-08-30 | AWAY | Ajax Amsterdam | 4-0 |
| Eredivisie | 5 | 2015-09-13 | HOME | Heracles Almelo | 0-1 |
| Eredivisie | 6 | 2015-09-19 | AWAY | FC Zwolle | 2-1 |
| Eredivisie | 7 | 2015-09-27 | HOME | Excelsior Rotterdam | 3-3 |
| Eredivisie | 8 | 2015-10-03 | AWAY | NEC Nijmegen | 4-1 |
| Eredivisie | 9 | 2015-10-18 | HOME | De Graafschap Doetinchem | 1-1 |
| Eredivisie | 10 | 2015-10-25 | AWAY | Cambuur Leeuwarden | 1-1 |
| Eredivisie | 11 | 2015-11-01 | HOME | Feyenoord Rotterdam | 1-0 |
| Eredivisie | 12 | 2015-11-06 | AWAY | Roda JC Kerkrade | 1-1 |
| Eredivisie | 13 | 2015-11-22 | HOME | Vitesse Arnheim | 2-2 |
| Eredivisie | 14 | 2015-11-29 | AWAY | FC Groningen | 2-1 |
| Eredivisie | 15 | 2015-12-04 | AWAY | AZ Alkmaar | 0-1 |
| Eredivisie | 16 | 2015-12-12 | HOME | Willem II Tilburg | 1-1 |
| Eredivisie | 17 | 2015-12-20 | AWAY | SC Heerenveen | 0-4 |
| Eredivisie | 18 | 2016-01-17 | HOME | Ajax Amsterdam | 0-1 |
| Eredivisie | 19 | 2016-01-24 | HOME | Cambuur Leeuwarden | 2-1 |
| Eredivisie | 20 | 2016-01-27 | AWAY | De Graafschap Doetinchem | 3-1 |
| Eredivisie | 21 | 2016-01-31 | AWAY | Feyenoord Rotterdam | 0-2 |
| Eredivisie | 22 | 2016-02-06 | HOME | Roda JC Kerkrade | 2-2 |
| Eredivisie | 23 | 2016-02-14 | AWAY | Excelsior Rotterdam | 2-4 |
| Eredivisie | 24 | 2016-02-19 | HOME | FC Zwolle | 0-2 |
| Eredivisie | 25 | 2016-02-27 | AWAY | PSV Eindhoven | 2-0 |
| Eredivisie | 26 | 2016-03-04 | HOME | Twente Enschede | 2-1 |
| Eredivisie | 27 | 2016-03-13 | AWAY | FC Utrecht | |
| Eredivisie | 28 | 2016-03-20 | HOME | NEC Nijmegen | |
| Eredivisie | 29 | 2016-04-03 | HOME | FC Groningen | |
| Eredivisie | 30 | 2016-04-09 | AWAY | Vitesse Arnheim | |
| Eredivisie | 31 | 2016-04-17 | AWAY | Willem II Tilburg | |
| Eredivisie | 32 | 2016-04-20 | HOME | AZ Alkmaar | |
| Eredivisie | 33 | 2016-05-01 | AWAY | Heracles Almelo | |
| Eredivisie | 34 | 2016-05-08 | HOME | SC Heerenveen |
