| Eredivisie | 1 | 2015-08-11 | AWAY | SC Heerenveen | 3-1 |
| Eredivisie | 2 | 2015-08-15 | HOME | FC Zwolle | 0-3 |
| Eredivisie | 3 | 2015-08-22 | AWAY | Roda JC Kerkrade | 1-0 |
| Eredivisie | 4 | 2015-08-29 | AWAY | Excelsior Rotterdam | 3-0 |
| Eredivisie | 5 | 2015-09-12 | HOME | AZ Alkmaar | 1-3 |
| Eredivisie | 6 | 2015-09-20 | AWAY | Vitesse Arnheim | 3-0 |
| Eredivisie | 7 | 2015-09-27 | HOME | Willem II Tilburg | 2-2 |
| Eredivisie | 8 | 2015-10-04 | HOME | Feyenoord Rotterdam | 1-2 |
| Eredivisie | 9 | 2015-10-18 | AWAY | Den Haag ADO | 1-1 |
| Eredivisie | 10 | 2015-10-24 | HOME | Heracles Almelo | 0-1 |
| Eredivisie | 11 | 2015-10-31 | HOME | PSV Eindhoven | 3-6 |
| Eredivisie | 12 | 2015-11-07 | AWAY | NEC Nijmegen | 2-0 |
| Eredivisie | 13 | 2015-11-21 | HOME | FC Groningen | 1-2 |
| Eredivisie | 14 | 2015-11-27 | AWAY | Cambuur Leeuwarden | 2-3 |
| Eredivisie | 15 | 2015-12-05 | HOME | FC Utrecht | 0-1 |
| Eredivisie | 16 | 2015-12-12 | AWAY | Twente Enschede | 2-1 |
| Eredivisie | 17 | 2015-12-20 | AWAY | Ajax Amsterdam | 2-1 |
| Eredivisie | 18 | 2016-01-16 | HOME | Excelsior Rotterdam | 2-0 |
| Eredivisie | 19 | 2016-01-23 | AWAY | Heracles Almelo | 2-1 |
| Eredivisie | 20 | 2016-01-27 | HOME | Den Haag ADO | 3-1 |
| Eredivisie | 21 | 2016-01-30 | AWAY | PSV Eindhoven | 4-2 |
| Eredivisie | 22 | 2016-02-07 | HOME | NEC Nijmegen | 1-1 |
| Eredivisie | 23 | 2016-02-13 | AWAY | Willem II Tilburg | 0-0 |
| Eredivisie | 24 | 2016-02-21 | HOME | Vitesse Arnheim | 2-2 |
| Eredivisie | 25 | 2016-02-28 | HOME | SC Heerenveen | 0-1 |
| Eredivisie | 26 | 2016-03-05 | AWAY | FC Zwolle | 2-1 |
| Eredivisie | 27 | 2016-03-11 | HOME | Roda JC Kerkrade | |
| Eredivisie | 28 | 2016-03-19 | AWAY | Feyenoord Rotterdam | |
| Eredivisie | 29 | 2016-04-02 | HOME | Cambuur Leeuwarden | |
| Eredivisie | 30 | 2016-04-10 | AWAY | FC Groningen | |
| Eredivisie | 31 | 2016-04-15 | HOME | Twente Enschede | |
| Eredivisie | 32 | 2016-04-20 | AWAY | FC Utrecht | |
| Eredivisie | 33 | 2016-05-01 | AWAY | AZ Alkmaar | |
| Eredivisie | 34 | 2016-05-08 | HOME | Ajax Amsterdam |
