| Ligue 1 | 1 | 2015-08-08 | AWAY | ES Troyes AC | 0-0 |
| Ligue 1 | 2 | 2015-08-16 | AWAY | FC Paris Saint Germain | 2-0 |
| Ligue 1 | 3 | 2015-08-22 | HOME | SCO Angers | 0-2 |
| Ligue 1 | 4 | 2015-08-29 | AWAY | OSC Lille | 1-0 |
| Ligue 1 | 5 | 2015-09-13 | HOME | AS Monaco | 0-1 |
| Ligue 1 | 6 | 2015-09-19 | AWAY | En Avant Guingamp | 2-1 |
| Ligue 1 | 7 | 2015-09-23 | HOME | Stade Rennes | 1-1 |
| Ligue 1 | 8 | 2015-09-26 | AWAY | Stade Malherbe Caen | 2-0 |
| Ligue 1 | 9 | 2015-10-03 | HOME | Toulouse FC | 2-2 |
| Ligue 1 | 10 | 2015-10-17 | AWAY | AS Saint Etienne | 2-0 |
| Ligue 1 | 11 | 2015-10-24 | HOME | OGC Nice | 3-1 |
| Ligue 1 | 12 | 2015-10-31 | HOME | Girondins Bordeaux | 2-0 |
| Ligue 1 | 13 | 2015-11-07 | AWAY | Stade Reims | 1-2 |
| Ligue 1 | 14 | 2015-11-22 | AWAY | SC Bastia | 1-2 |
| Ligue 1 | 15 | 2015-11-28 | HOME | FC Lorient | 1-1 |
| Ligue 1 | 16 | 2015-12-02 | AWAY | SC Montpellier | 0-2 |
| Ligue 1 | 17 | 2015-12-05 | HOME | FC Nantes | 1-1 |
| Ligue 1 | 18 | 2015-12-13 | AWAY | Olympique Marseille | 1-1 |
| Ligue 1 | 19 | 2015-12-20 | HOME | Olympique Lyon | 2-1 |
| Ligue 1 | 20 | 2016-01-09 | AWAY | AS Monaco | 2-2 |
| Ligue 1 | 21 | 2016-01-16 | HOME | Stade Reims | 2-2 |
| Ligue 1 | 22 | 2016-01-22 | AWAY | Stade Rennes | 1-0 |
| Ligue 1 | 23 | 2016-01-30 | HOME | SC Montpellier | 0-4 |
| Ligue 1 | 24 | 2016-02-03 | AWAY | FC Nantes | 3-1 |
| Ligue 1 | 25 | 2016-02-06 | HOME | En Avant Guingamp | 0-0 |
| Ligue 1 | 26 | 2016-02-13 | HOME | ES Troyes AC | 2-3 |
| Ligue 1 | 27 | 2016-02-20 | AWAY | Toulouse FC | 1-1 |
| Ligue 1 | 29 | 2016-03-05 | AWAY | Girondins Bordeaux | 1-1 |
| Ligue 1 | 28 | 2016-03-09 | HOME | Olympique Marseille | |
| Ligue 1 | 30 | 2016-03-12 | HOME | Stade Malherbe Caen | |
| Ligue 1 | 31 | 2016-03-20 | AWAY | OGC Nice | |
| Ligue 1 | 32 | 2016-04-02 | HOME | AS Saint Etienne | |
| Ligue 1 | 33 | 2016-04-09 | AWAY | SCO Angers | |
| Ligue 1 | 34 | 2016-04-16 | HOME | OSC Lille | |
| Ligue 1 | 35 | 2016-04-24 | HOME | SC Bastia | |
| Ligue 1 | 36 | 2016-04-30 | AWAY | Olympique Lyon | |
| Ligue 1 | 37 | 2016-05-07 | HOME | FC Paris Saint Germain | |
| Ligue 1 | 38 | 2016-05-14 | AWAY | FC Lorient |
