| Ligue 1 | 1 | 2015-08-08 | HOME | GFC Ajaccio | 0-0 |
| Ligue 1 | 2 | 2015-08-15 | HOME | OGC Nice | 3-3 |
| Ligue 1 | 3 | 2015-08-23 | AWAY | Olympique Marseille | 6-0 |
| Ligue 1 | 4 | 2015-08-29 | HOME | SC Montpellier | 0-0 |
| Ligue 1 | 5 | 2015-09-12 | HOME | Stade Malherbe Caen | 1-3 |
| Ligue 1 | 6 | 2015-09-19 | AWAY | SCO Angers | 1-0 |
| Ligue 1 | 7 | 2015-09-23 | HOME | AS Saint Etienne | 0-1 |
| Ligue 1 | 8 | 2015-09-26 | AWAY | Stade Rennes | 1-1 |
| Ligue 1 | 9 | 2015-10-03 | HOME | En Avant Guingamp | 0-1 |
| Ligue 1 | 10 | 2015-10-17 | AWAY | FC Nantes | 3-0 |
| Ligue 1 | 11 | 2015-10-25 | AWAY | Girondins Bordeaux | 1-0 |
| Ligue 1 | 12 | 2015-10-31 | HOME | Olympique Lyon | 0-1 |
| Ligue 1 | 13 | 2015-11-07 | AWAY | FC Lorient | 4-1 |
| Ligue 1 | 14 | 2015-11-21 | HOME | OSC Lille | 1-1 |
| Ligue 1 | 15 | 2015-11-28 | AWAY | FC Paris Saint Germain | 4-1 |
| Ligue 1 | 16 | 2015-12-02 | HOME | Toulouse FC | 0-3 |
| Ligue 1 | 17 | 2015-12-05 | AWAY | Stade Reims | 1-1 |
| Ligue 1 | 18 | 2015-12-12 | HOME | SC Bastia | 1-1 |
| Ligue 1 | 19 | 2015-12-19 | HOME | AS Monaco | 0-0 |
| Ligue 1 | 20 | 2016-01-09 | AWAY | Olympique Lyon | 4-1 |
| Ligue 1 | 21 | 2016-01-16 | HOME | Stade Rennes | 2-4 |
| Ligue 1 | 22 | 2016-01-23 | AWAY | OSC Lille | 1-3 |
| Ligue 1 | 23 | 2016-01-30 | HOME | FC Nantes | 0-1 |
| Ligue 1 | 24 | 2016-02-03 | AWAY | En Avant Guingamp | 4-0 |
| Ligue 1 | 25 | 2016-02-06 | AWAY | SC Bastia | 2-0 |
| Ligue 1 | 26 | 2016-02-13 | AWAY | GFC Ajaccio | 2-3 |
| Ligue 1 | 27 | 2016-02-20 | AWAY | AS Monaco | 3-1 |
| Ligue 1 | 28 | 2016-02-27 | HOME | FC Lorient | 0-1 |
| Ligue 1 | 29 | 2016-03-05 | AWAY | OGC Nice | 2-1 |
| Ligue 1 | 30 | 2016-03-13 | HOME | FC Paris Saint Germain | |
| Ligue 1 | 31 | 2016-03-19 | AWAY | Stade Malherbe Caen | |
| Ligue 1 | 32 | 2016-04-02 | HOME | SCO Angers | |
| Ligue 1 | 33 | 2016-04-09 | AWAY | AS Saint Etienne | |
| Ligue 1 | 34 | 2016-04-16 | HOME | Stade Reims | |
| Ligue 1 | 35 | 2016-04-24 | AWAY | SC Montpellier | |
| Ligue 1 | 36 | 2016-04-30 | HOME | Girondins Bordeaux | |
| Ligue 1 | 37 | 2016-05-07 | AWAY | Toulouse FC | |
| Ligue 1 | 38 | 2016-05-14 | HOME | Olympique Marseille |
