| Ligue 1 | 1 | 2018-08-11 | AWAY | SC Montpellier | 1-2 |
| Ligue 1 | 2 | 2018-08-18 | HOME | FC Nantes | 2-0 |
| Ligue 1 | 3 | 2018-08-25 | AWAY | OGC Nice | 0-4 |
| Ligue 1 | 4 | 2018-09-01 | HOME | Stade Malherbe Caen | 0-2 |
| Ligue 1 | 5 | 2018-09-15 | HOME | SCO Angers | 1-3 |
| Ligue 1 | 6 | 2018-09-22 | AWAY | Stade Reims | 0-0 |
| Ligue 1 | 7 | 2018-09-26 | HOME | Olympique Lyon | 0-3 |
| Ligue 1 | 8 | 2018-09-29 | AWAY | Racing Strasbourg | 3-0 |
| Ligue 1 | 9 | 2018-10-06 | AWAY | Amiens SC | 1-0 |
| Ligue 1 | 10 | 2018-10-20 | HOME | OSC Lille | 1-2 |
| Ligue 1 | 11 | 2018-10-27 | AWAY | AS Monaco | 2-2 |
| Ligue 1 | 12 | 2018-11-03 | HOME | Nimes Olympique | 0-4 |
| Ligue 1 | 13 | 2018-11-11 | AWAY | Olympique Marseille | 2-0 |
| Ligue 1 | 14 | 2018-11-24 | HOME | Girondins Bordeaux | 0-0 |
| Ligue 1 | 15 | 2018-12-02 | AWAY | Toulouse FC | |
| Ligue 1 | 16 | 2018-12-05 | HOME | En Avant Guingamp | |
| Ligue 1 | 17 | 2018-12-08 | AWAY | Stade Rennes | |
| Ligue 1 | 18 | 2018-12-15 | HOME | FC Paris Saint Germain | |
| Ligue 1 | 19 | 2018-12-22 | AWAY | AS Saint Etienne | |
| Ligue 1 | 20 | 2019-01-12 | HOME | SC Montpellier | |
| Ligue 1 | 21 | 2019-01-19 | AWAY | Girondins Bordeaux | |
| Ligue 1 | 22 | 2019-01-26 | HOME | AS Monaco | |
| Ligue 1 | 23 | 2019-02-02 | AWAY | SCO Angers | |
| Ligue 1 | 24 | 2019-02-09 | HOME | Olympique Marseille | |
| Ligue 1 | 25 | 2019-02-16 | AWAY | Nimes Olympique | |
| Ligue 1 | 26 | 2019-02-23 | HOME | AS Saint Etienne | |
| Ligue 1 | 27 | 2019-03-02 | AWAY | OSC Lille | |
| Ligue 1 | 28 | 2019-03-09 | HOME | Stade Reims | |
| Ligue 1 | 29 | 2019-03-16 | AWAY | En Avant Guingamp | |
| Ligue 1 | 30 | 2019-03-31 | HOME | OGC Nice | |
| Ligue 1 | 31 | 2019-04-06 | AWAY | Olympique Lyon | |
| Ligue 1 | 32 | 2019-04-13 | HOME | Amiens SC | |
| Ligue 1 | 33 | 2019-04-20 | HOME | Stade Rennes | |
| Ligue 1 | 34 | 2019-04-28 | AWAY | Stade Malherbe Caen | |
| Ligue 1 | 35 | 2019-05-04 | AWAY | FC Nantes | |
| Ligue 1 | 36 | 2019-05-11 | HOME | Racing Strasbourg | |
| Ligue 1 | 37 | 2019-05-18 | AWAY | FC Paris Saint Germain | |
| Ligue 1 | 38 | 2019-05-25 | HOME | Toulouse FC |
