| Premier League | 1 | 1920-08-28 | HOME | Everton | 3-3 |
| Premier League | 2 | 1920-09-01 | AWAY | Sunderland | 5-1 |
| Premier League | 3 | 1920-09-04 | AWAY | Everton | 1-1 |
| Premier League | 4 | 1920-09-08 | HOME | Sunderland | 1-1 |
| Premier League | 5 | 1920-09-11 | HOME | Sheffield United | 2-0 |
| Premier League | 6 | 1920-09-18 | AWAY | Sheffield United | 2-0 |
| Premier League | 7 | 1920-09-25 | HOME | Bradford City | 1-2 |
| Premier League | 8 | 1920-10-02 | AWAY | Bradford City | 2-1 |
| Premier League | 9 | 1920-10-09 | HOME | Burnley | 1-3 |
| Premier League | 10 | 1920-10-16 | AWAY | Burnley | 1-0 |
| Premier League | 11 | 1920-10-23 | AWAY | Newcastle United | 2-1 |
| Premier League | 12 | 1920-10-30 | HOME | Newcastle United | 0-2 |
| Premier League | 13 | 1920-11-06 | AWAY | Liverpool | 0-1 |
| Premier League | 14 | 1920-11-13 | HOME | Liverpool | 1-3 |
| Premier League | 16 | 1920-11-20 | AWAY | Aston Villa | 4-1 |
| Premier League | 17 | 1920-11-27 | HOME | Aston Villa | 4-0 |
| Premier League | 17 | 1920-12-04 | AWAY | Manchester United | 5-1 |
| Premier League | 18 | 1920-12-11 | HOME | Manchester United | 2-4 |
| Premier League | 19 | 1920-12-18 | AWAY | Chelsea | 4-1 |
| Premier League | 20 | 1920-12-25 | AWAY | Oldham Athletic | 1-0 |
| Premier League | 21 | 1920-12-27 | HOME | Oldham Athletic | 2-1 |
| Premier League | 22 | 1921-01-01 | HOME | Chelsea | 0-2 |
| Premier League | 23 | 1921-01-15 | HOME | Huddersfield | 1-1 |
| Premier League | 24 | 1921-01-22 | AWAY | Huddersfield | 0-0 |
| Premier League | 25 | 1921-02-03 | AWAY | Tottenham Hotspur | 2-0 |
| Premier League | 26 | 1921-02-05 | HOME | Tottenham Hotspur | 1-1 |
| Premier League | 27 | 1921-02-12 | HOME | Middlesbrough | 3-0 |
| Premier League | 28 | 1921-02-19 | AWAY | Middlesbrough | 2-1 |
| Premier League | 29 | 1921-02-26 | HOME | Blackburn Rovers | 1-1 |
| Premier League | 30 | 1921-03-05 | AWAY | Blackburn Rovers | 1-0 |
| Premier League | 31 | 1921-03-12 | HOME | Derby County | 2-1 |
| Premier League | 32 | 1921-03-19 | AWAY | Derby County | 1-0 |
| Premier League | 33 | 1921-03-25 | AWAY | Preston North End | 3-3 |
| Premier League | 34 | 1921-03-26 | AWAY | Bolton Wanderers | 2-0 |
| Premier League | 35 | 1921-03-28 | HOME | Preston North End | 1-3 |
| Premier League | 36 | 1921-04-02 | HOME | Bolton Wanderers | 2-1 |
| Premier League | 37 | 1921-04-09 | AWAY | Arsenal | 2-1 |
| Premier League | 38 | 1921-04-16 | HOME | Arsenal | 0-1 |
| Premier League | 39 | 1921-04-23 | AWAY | Manchester City | 1-0 |
| Premier League | 40 | 1921-04-30 | HOME | Manchester City | 1-2 |
| Premier League | 41 | 1921-05-02 | AWAY | West Bromwich Albion | 0-1 |
| Premier League | 42 | 1921-05-07 | HOME | West Bromwich Albion | 0-3 |
