| Jupiler League | 1 | 2015-07-26 | AWAY | Royal Charleroi SC | 2-1 |
| Jupiler League | 2 | 2015-08-01 | HOME | Sint-Truidense VV | 0-2 |
| Jupiler League | 3 | 2015-08-08 | AWAY | KV Mechelen | 3-1 |
| Jupiler League | 4 | 2015-08-15 | HOME | Standard Liege | 1-1 |
| Jupiler League | 5 | 2015-08-22 | AWAY | Waasland-Beveren | 3-3 |
| Jupiler League | 6 | 2015-08-29 | HOME | KV Kortrijk | 0-1 |
| Jupiler League | 7 | 2015-09-11 | HOME | Club Brugge KV | 2-1 |
| Jupiler League | 8 | 2015-09-19 | AWAY | Sporting Lokeren | 1-2 |
| Jupiler League | 9 | 2015-09-26 | HOME | KV Oostende | 2-2 |
| Jupiler League | 10 | 2015-10-03 | AWAY | OH Leuven | 1-1 |
| Jupiler League | 11 | 2015-10-16 | HOME | KAA Gent | 1-2 |
| Jupiler League | 12 | 2015-10-23 | AWAY | KRC Genk | 0-4 |
| Jupiler League | 13 | 2015-10-27 | HOME | KVC Westerlo | 2-2 |
| Jupiler League | 14 | 2015-11-01 | AWAY | RSC Anderlecht | 2-0 |
| Jupiler League | 15 | 2015-11-06 | HOME | SV Zulte-Waregem | 2-2 |
| Jupiler League | 17 | 2015-11-28 | AWAY | Sint-Truidense VV | 0-1 |
| Jupiler League | 18 | 2015-12-05 | HOME | KV Mechelen | 2-3 |
| Jupiler League | 19 | 2015-12-12 | AWAY | KV Kortrijk | 1-3 |
| Jupiler League | 20 | 2015-12-19 | HOME | Waasland-Beveren | 0-1 |
| Jupiler League | 16 | 2015-12-22 | HOME | Royal Charleroi SC | 0-1 |
| Jupiler League | 21 | 2015-12-27 | AWAY | Standard Liege | 3-0 |
| Jupiler League | 22 | 2016-01-16 | AWAY | Club Brugge KV | 3-0 |
| Jupiler League | 23 | 2016-01-23 | HOME | Sporting Lokeren | 1-1 |
| Jupiler League | 24 | 2016-01-31 | AWAY | KV Oostende | 3-3 |
| Jupiler League | 25 | 2016-02-06 | HOME | KRC Genk | 0-1 |
| Jupiler League | 26 | 2016-02-12 | AWAY | KAA Gent | 2-0 |
| Jupiler League | 27 | 2016-02-20 | HOME | OH Leuven | 3-1 |
| Jupiler League | 28 | 2016-02-27 | AWAY | KVC Westerlo | 2-2 |
| Jupiler League | 29 | 2016-03-05 | HOME | RSC Anderlecht | 2-1 |
| Jupiler League | 30 | 2016-03-13 | AWAY | SV Zulte-Waregem |
