| Jupiler League | 1 | 2005-08-06 | AWAY | RSC Anderlecht | 6-0 |
| Jupiler League | 2 | 2005-08-12 | HOME | KAA Gent | 1-1 |
| Jupiler League | 3 | 2005-08-20 | AWAY | SV Zulte-Waregem | 0-0 |
| Jupiler League | 4 | 2005-08-27 | HOME | Standard Liege | 2-3 |
| Jupiler League | 5 | 2005-09-10 | HOME | Cercle Brugge KSV | 0-0 |
| Jupiler League | 6 | 2005-09-18 | AWAY | Germinal Beerschot | 1-1 |
| Jupiler League | 7 | 2005-09-21 | HOME | KRC Genk | 2-3 |
| Jupiler League | 8 | 2005-09-24 | AWAY | Royal Excelsior Mouscron | 2-1 |
| Jupiler League | 9 | 2005-10-01 | HOME | FC Brussels | 0-3 |
| Jupiler League | 10 | 2005-10-15 | AWAY | KSV Roeselare | 4-1 |
| Jupiler League | 11 | 2005-10-22 | HOME | Lierse SK | 1-0 |
| Jupiler League | 12 | 2005-10-29 | AWAY | Sint-Truidense VV | 1-3 |
| Jupiler League | 13 | 2005-11-05 | HOME | KSK Beveren | 2-0 |
| Jupiler League | 14 | 2005-11-19 | AWAY | Club Brugge KV | 4-0 |
| Jupiler League | 16 | 2005-12-03 | AWAY | Royal Charleroi SC | 0-2 |
| Jupiler League | 17 | 2005-12-10 | HOME | KVC Westerlo | 0-3 |
| Jupiler League | 15 | 2005-12-14 | HOME | Sporting Lokeren | 1-1 |
| Jupiler League | 18 | 2005-12-18 | HOME | RSC Anderlecht | 0-0 |
| Jupiler League | 19 | 2006-01-21 | AWAY | KAA Gent | 3-0 |
| Jupiler League | 20 | 2006-01-28 | HOME | SV Zulte-Waregem | 2-2 |
| Jupiler League | 22 | 2006-02-11 | AWAY | Cercle Brugge KSV | 1-0 |
| Jupiler League | 23 | 2006-02-19 | HOME | Germinal Beerschot | 1-1 |
| Jupiler League | 21 | 2006-02-22 | AWAY | Standard Liege | 1-1 |
| Jupiler League | 24 | 2006-02-25 | AWAY | KRC Genk | 1-0 |
| Jupiler League | 25 | 2006-03-04 | HOME | Royal Excelsior Mouscron | 0-0 |
| Jupiler League | 26 | 2006-03-11 | AWAY | FC Brussels | 0-0 |
| Jupiler League | 27 | 2006-03-18 | HOME | KSV Roeselare | 0-0 |
| Jupiler League | 28 | 2006-03-25 | AWAY | Lierse SK | 0-0 |
| Jupiler League | 29 | 2006-04-01 | HOME | Sint-Truidense VV | 0-2 |
| Jupiler League | 30 | 2006-04-08 | AWAY | KSK Beveren | 1-0 |
| Jupiler League | 31 | 2006-04-16 | HOME | Club Brugge KV | 0-1 |
| Jupiler League | 32 | 2006-04-22 | AWAY | Sporting Lokeren | 3-2 |
| Jupiler League | 33 | 2006-04-30 | HOME | Royal Charleroi SC | 2-2 |
| Jupiler League | 34 | 2006-05-05 | AWAY | KVC Westerlo | 2-1 |
