| Jupiler League | 1 | 2000-08-13 | HOME | Standard Liege | 3-4 |
| Jupiler League | 2 | 2000-08-19 | AWAY | Royal Charleroi SC | 5-0 |
| Jupiler League | 3 | 2000-08-27 | HOME | RAA La Louviere | 2-2 |
| Jupiler League | 4 | 2000-09-06 | AWAY | Royal Antwerpen FC | 2-0 |
| Jupiler League | 5 | 2000-09-10 | HOME | Germinal Beerschot | 3-0 |
| Jupiler League | 6 | 2000-09-16 | AWAY | RSC Anderlecht | 4-3 |
| Jupiler League | 7 | 2000-09-24 | HOME | Club Brugge KV | 0-6 |
| Jupiler League | 8 | 2000-09-30 | AWAY | Lierse SK | 4-1 |
| Jupiler League | 9 | 2000-10-15 | HOME | KV Mechelen | 1-0 |
| Jupiler League | 10 | 2000-10-21 | AWAY | KRC Genk | 4-0 |
| Jupiler League | 11 | 2000-10-29 | HOME | KSC Eendracht Aalst | 2-4 |
| Jupiler League | 12 | 2000-11-11 | AWAY | KAA Gent | 2-1 |
| Jupiler League | 13 | 2000-11-19 | HOME | Sint-Truidense VV | 0-4 |
| Jupiler League | 14 | 2000-11-25 | AWAY | Royal Excelsior Mouscron | 4-3 |
| Jupiler League | 15 | 2000-12-03 | HOME | KVC Westerlo | 0-4 |
| Jupiler League | 16 | 2000-12-10 | HOME | Sporting Lokeren | 1-6 |
| Jupiler League | 17 | 2000-12-16 | AWAY | KSK Beveren | 2-1 |
| Jupiler League | 18 | 2000-12-20 | AWAY | Standard Liege | 3-0 |
| Jupiler League | 19 | 2001-01-21 | HOME | Royal Charleroi SC | 1-0 |
| Jupiler League | 20 | 2001-01-28 | AWAY | RAA La Louviere | 0-2 |
| Jupiler League | 21 | 2001-02-04 | HOME | Royal Antwerpen FC | 2-0 |
| Jupiler League | 22 | 2001-02-10 | AWAY | Germinal Beerschot | 2-1 |
| Jupiler League | 23 | 2001-02-18 | HOME | RSC Anderlecht | 1-4 |
| Jupiler League | 24 | 2001-03-04 | AWAY | Club Brugge KV | 0-0 |
| Jupiler League | 25 | 2001-03-11 | HOME | Lierse SK | 1-0 |
| Jupiler League | 26 | 2001-03-18 | AWAY | KV Mechelen | 2-0 |
| Jupiler League | 27 | 2001-04-01 | HOME | KRC Genk | 1-2 |
| Jupiler League | 28 | 2001-04-07 | AWAY | KSC Eendracht Aalst | 0-0 |
| Jupiler League | 29 | 2001-04-14 | HOME | KAA Gent | 2-1 |
| Jupiler League | 30 | 2001-04-21 | AWAY | Sint-Truidense VV | 1-1 |
| Jupiler League | 31 | 2001-04-29 | HOME | Royal Excelsior Mouscron | 0-1 |
| Jupiler League | 32 | 2001-05-06 | AWAY | KVC Westerlo | 1-0 |
| Jupiler League | 33 | 2001-05-06 | AWAY | Sporting Lokeren | 3-0 |
| Jupiler League | 34 | 2001-05-20 | HOME | KSK Beveren | 3-2 |
