| Jupiler League | 1 | 1999-08-06 | HOME | KAA Gent | 1-5 |
| Jupiler League | 2 | 1999-08-14 | AWAY | Sint-Truidense VV | 1-1 |
| Jupiler League | 3 | 1999-08-21 | HOME | KRC Genk | 1-1 |
| Jupiler League | 4 | 1999-08-22 | AWAY | Sporting Lokeren | 0-0 |
| Jupiler League | 5 | 1999-09-11 | HOME | Standard Liege | 0-0 |
| Jupiler League | 6 | 1999-09-18 | AWAY | Germinal Beerschot | 4-1 |
| Jupiler League | 7 | 1999-09-26 | HOME | Royal Charleroi SC | 0-0 |
| Jupiler League | 9 | 1999-10-03 | HOME | Royal Excelsior Mouscron | 1-4 |
| Jupiler League | 8 | 1999-10-03 | AWAY | KSC Eendracht Aalst | 1-0 |
| Jupiler League | 10 | 1999-10-24 | AWAY | RSC Anderlecht | 4-0 |
| Jupiler League | 11 | 1999-10-30 | HOME | KSK Beveren | 1-1 |
| Jupiler League | 12 | 1999-11-07 | AWAY | KRC Harelbeke | 3-0 |
| Jupiler League | 13 | 1999-11-07 | HOME | Lierse SK | 2-1 |
| Jupiler League | 14 | 1999-11-20 | AWAY | KV Mechelen | 1-1 |
| Jupiler League | 15 | 1999-11-27 | HOME | KFC Lommelse SK | 0-0 |
| Jupiler League | 16 | 1999-12-04 | HOME | KVC Westerlo | 2-3 |
| Jupiler League | 17 | 1999-12-11 | AWAY | Club Brugge KV | 4-0 |
| Jupiler League | 18 | 2000-01-12 | AWAY | KAA Gent | 1-1 |
| Jupiler League | 19 | 2000-01-15 | HOME | Sint-Truidense VV | 1-2 |
| Jupiler League | 20 | 2000-01-22 | AWAY | KRC Genk | 1-0 |
| Jupiler League | 21 | 2000-01-29 | HOME | Sporting Lokeren | 3-0 |
| Jupiler League | 22 | 2000-02-06 | AWAY | Standard Liege | 3-0 |
| Jupiler League | 23 | 2000-02-12 | HOME | Germinal Beerschot | 0-2 |
| Jupiler League | 24 | 2000-02-19 | AWAY | Royal Charleroi SC | 1-3 |
| Jupiler League | 25 | 2000-03-04 | HOME | KSC Eendracht Aalst | 1-2 |
| Jupiler League | 26 | 2000-03-11 | AWAY | Royal Excelsior Mouscron | 3-1 |
| Jupiler League | 27 | 2000-03-18 | HOME | RSC Anderlecht | 0-0 |
| Jupiler League | 28 | 2000-03-25 | AWAY | KSK Beveren | 1-1 |
| Jupiler League | 29 | 2000-04-02 | HOME | KRC Harelbeke | 3-2 |
| Jupiler League | 30 | 2000-04-07 | AWAY | Lierse SK | 2-2 |
| Jupiler League | 31 | 2000-04-16 | HOME | KV Mechelen | 3-0 |
| Jupiler League | 32 | 2000-04-22 | AWAY | KFC Lommelse SK | 1-1 |
| Jupiler League | 33 | 2000-05-06 | AWAY | KVC Westerlo | 4-1 |
| Jupiler League | 34 | 2000-05-11 | HOME | Club Brugge KV | 0-2 |
