| Jupiler League | 1 | 2012-07-28 | HOME | Sporting Lokeren | 2-4 |
| Jupiler League | 2 | 2012-08-04 | AWAY | RSC Anderlecht | 1-0 |
| Jupiler League | 3 | 2012-08-11 | HOME | SV Zulte-Waregem | 1-1 |
| Jupiler League | 4 | 2012-08-18 | AWAY | Club Brugge KV | 3-1 |
| Jupiler League | 5 | 2012-08-25 | HOME | Royal Charleroi SC | 2-0 |
| Jupiler League | 6 | 2012-09-01 | AWAY | KV Mechelen | 0-2 |
| Jupiler League | 7 | 2012-09-16 | HOME | Standard Liege | 3-2 |
| Jupiler League | 8 | 2012-09-22 | HOME | KV Kortrijk | 2-1 |
| Jupiler League | 9 | 2012-09-29 | AWAY | RAEC Mons | 1-0 |
| Jupiler League | 10 | 2012-10-05 | HOME | KAA Gent | 2-2 |
| Jupiler League | 11 | 2012-10-20 | AWAY | KRC Genk | 3-0 |
| Jupiler League | 12 | 2012-10-27 | HOME | OH Leuven | 1-3 |
| Jupiler League | 13 | 2012-10-31 | AWAY | Cercle Brugge KSV | 3-1 |
| Jupiler League | 14 | 2012-11-03 | HOME | Waasland-Beveren | 1-2 |
| Jupiler League | 15 | 2012-11-10 | AWAY | Lierse SK | 1-3 |
| Jupiler League | 16 | 2012-11-18 | AWAY | Sporting Lokeren | 1-0 |
| Jupiler League | 17 | 2012-11-24 | HOME | RSC Anderlecht | 1-4 |
| Jupiler League | 18 | 2012-12-01 | AWAY | SV Zulte-Waregem | 0-0 |
| Jupiler League | 19 | 2012-12-09 | HOME | Club Brugge KV | 1-7 |
| Jupiler League | 20 | 2012-12-15 | AWAY | Royal Charleroi SC | 1-0 |
| Jupiler League | 21 | 2012-12-22 | HOME | KV Mechelen | 0-2 |
| Jupiler League | 22 | 2012-12-27 | AWAY | Standard Liege | 3-0 |
| Jupiler League | 23 | 2013-01-19 | AWAY | KV Kortrijk | 4-0 |
| Jupiler League | 24 | 2013-01-26 | HOME | RAEC Mons | 0-0 |
| Jupiler League | 25 | 2013-02-02 | AWAY | KAA Gent | 2-1 |
| Jupiler League | 26 | 2013-02-09 | HOME | KRC Genk | 0-2 |
| Jupiler League | 27 | 2013-02-16 | AWAY | OH Leuven | 1-1 |
| Jupiler League | 28 | 2013-02-23 | HOME | Lierse SK | 1-3 |
| Jupiler League | 29 | 2013-03-09 | AWAY | Waasland-Beveren | 3-2 |
| Jupiler League | 30 | 2013-03-16 | HOME | Cercle Brugge KSV | 3-1 |
