| Jupiler League | 1 | 2010-07-31 | AWAY | RSC Anderlecht | 4-1 |
| Jupiler League | 2 | 2010-08-07 | HOME | KVC Westerlo | 0-1 |
| Jupiler League | 3 | 2010-08-14 | AWAY | KAA Gent | 2-1 |
| Jupiler League | 4 | 2010-08-22 | HOME | KRC Genk | 1-4 |
| Jupiler League | 5 | 2010-08-28 | AWAY | Royal Charleroi SC | 2-0 |
| Jupiler League | 6 | 2010-09-11 | AWAY | SV Zulte-Waregem | 0-0 |
| Jupiler League | 7 | 2010-09-18 | HOME | Germinal Beerschot | 0-1 |
| Jupiler League | 8 | 2010-09-22 | AWAY | Club Brugge KV | 4-0 |
| Jupiler League | 9 | 2010-09-25 | HOME | Sporting Lokeren | 0-1 |
| Jupiler League | 10 | 2010-10-02 | AWAY | KV Kortrijk | 3-1 |
| Jupiler League | 11 | 2010-10-16 | HOME | Sint-Truidense VV | 6-0 |
| Jupiler League | 12 | 2010-10-23 | AWAY | Cercle Brugge KSV | 2-1 |
| Jupiler League | 13 | 2010-10-30 | HOME | Lierse SK | 2-2 |
| Jupiler League | 14 | 2010-11-06 | AWAY | Standard Liege | 1-3 |
| Jupiler League | 15 | 2010-11-13 | HOME | KV Mechelen | 0-0 |
| Jupiler League | 16 | 2010-11-20 | HOME | KV Kortrijk | 3-1 |
| Jupiler League | 17 | 2010-11-27 | AWAY | KVC Westerlo | 1-1 |
| Jupiler League | 18 | 2010-12-04 | HOME | KAA Gent | 0-3 |
| Jupiler League | 19 | 2010-12-11 | AWAY | KRC Genk | 5-1 |
| Jupiler League | 20 | 2010-12-18 | HOME | Royal Charleroi SC | 1-0 |
| Jupiler League | 21 | 2010-12-26 | HOME | SV Zulte-Waregem | 0-0 |
| Jupiler League | 22 | 2010-12-29 | AWAY | Germinal Beerschot | 0-0 |
| Jupiler League | 23 | 2011-01-21 | HOME | Club Brugge KV | 1-4 |
| Jupiler League | 24 | 2011-01-29 | AWAY | Sporting Lokeren | 0-2 |
| Jupiler League | 25 | 2011-02-06 | HOME | Standard Liege | 0-1 |
| Jupiler League | 26 | 2011-02-12 | AWAY | Sint-Truidense VV | 1-1 |
| Jupiler League | 27 | 2011-02-19 | HOME | Cercle Brugge KSV | 0-0 |
| Jupiler League | 29 | 2011-02-26 | HOME | RSC Anderlecht | 1-1 |
| Jupiler League | 30 | 2011-03-05 | AWAY | KV Mechelen | 2-0 |
| Jupiler League | 28 | 2011-03-06 | AWAY | Lierse SK | 1-1 |
