| 2018-10-20 | AS Roma | 0-2 | Spal |
| 2018-10-20 | FC Juventus | 1-1 | Genoa CFC |
| 2018-10-20 | Udinese Calcio | 0-3 | SSC Napoli |
| 2018-10-21 | Frosinone Calcio | 3-3 | Empoli FC |
| 2018-10-21 | Bologna FC | 2-2 | Torino |
| 2018-10-21 | AC Chievo Verona | 1-5 | Atalanta BC |
| 2018-10-21 | Parma AC | 0-2 | SS Lazio |
| 2018-10-21 | AC Fiorentina | 1-1 | US Cagliari |
| 2018-10-21 | FC Internazionale | 1-0 | AC Milan |
| 2018-10-22 | UC Sampdoria | 0-0 | Sassuolo Calcio |
| Home | 1 |
| Draw | 5 |
| Away | 4 |
| Under | 6 |
| Over | 4 |
| Pos | Team | M. | W | D | L | GF | GA | Pts |
|---|---|---|---|---|---|---|---|---|
| 1 | FC Juventus | 9 | 8 | 1 | 0 | 19 | 6 | 25 |
| 2 | SSC Napoli | 9 | 7 | 0 | 2 | 18 | 10 | 21 |
| 3 | FC Internazionale | 9 | 6 | 1 | 2 | 13 | 6 | 19 |
| 4 | SS Lazio | 9 | 6 | 0 | 3 | 13 | 9 | 18 |
| 5 | UC Sampdoria | 9 | 4 | 3 | 2 | 12 | 4 | 15 |
| 6 | AC Milan | 9 | 4 | 3 | 2 | 17 | 12 | 15 |
| 7 | AC Fiorentina | 9 | 4 | 2 | 3 | 15 | 7 | 14 |
| 8 | AS Roma | 9 | 4 | 2 | 3 | 16 | 12 | 14 |
| 9 | Sassuolo Calcio | 9 | 4 | 2 | 3 | 15 | 14 | 14 |
| 10 | Torino | 9 | 3 | 4 | 2 | 11 | 11 | 13 |
| 11 | Parma AC | 9 | 4 | 1 | 4 | 10 | 11 | 13 |
| 12 | Genoa CFC | 9 | 4 | 1 | 4 | 14 | 17 | 13 |
| 13 | Spal | 9 | 4 | 0 | 5 | 8 | 10 | 12 |
| 14 | US Cagliari | 9 | 2 | 4 | 3 | 7 | 10 | 10 |
| 15 | Atalanta BC | 9 | 2 | 3 | 4 | 14 | 12 | 9 |
| 16 | Udinese Calcio | 9 | 2 | 2 | 5 | 8 | 13 | 8 |
| 17 | Bologna FC | 9 | 2 | 2 | 5 | 6 | 12 | 8 |
| 18 | Empoli FC | 9 | 1 | 3 | 5 | 8 | 13 | 6 |
| 19 | AC Chievo Verona | 9 | 0 | 2 | 7 | 7 | 24 | 2 |
| 20 | Frosinone Calcio | 9 | 0 | 2 | 7 | 6 | 24 | 2 |
