| 2018-10-05 | Torino | 3-2 | Frosinone Calcio |
| 2018-10-06 | US Cagliari | 2-0 | Bologna FC |
| 2018-10-06 | Udinese Calcio | 0-2 | FC Juventus |
| 2018-10-06 | Empoli FC | 0-2 | AS Roma |
| 2018-10-07 | Genoa CFC | 1-3 | Parma AC |
| 2018-10-07 | Atalanta BC | 0-1 | UC Sampdoria |
| 2018-10-07 | SS Lazio | 1-0 | AC Fiorentina |
| 2018-10-07 | AC Milan | 3-1 | AC Chievo Verona |
| 2018-10-07 | SSC Napoli | 2-0 | Sassuolo Calcio |
| 2018-10-07 | Spal | 1-2 | FC Internazionale |
| Home | 5 |
| Draw | 0 |
| Away | 5 |
| Under | 6 |
| Over | 4 |
| Pos | Team | M. | W | D | L | GF | GA | Pts |
|---|---|---|---|---|---|---|---|---|
| 1 | FC Juventus | 8 | 8 | 0 | 0 | 18 | 5 | 24 |
| 2 | SSC Napoli | 8 | 6 | 0 | 2 | 15 | 10 | 18 |
| 3 | FC Internazionale | 8 | 5 | 1 | 2 | 12 | 6 | 16 |
| 4 | AC Milan | 8 | 4 | 3 | 1 | 17 | 11 | 15 |
| 5 | SS Lazio | 8 | 5 | 0 | 3 | 11 | 9 | 15 |
| 6 | UC Sampdoria | 8 | 4 | 2 | 2 | 12 | 4 | 14 |
| 7 | AS Roma | 8 | 4 | 2 | 2 | 16 | 10 | 14 |
| 8 | AC Fiorentina | 8 | 4 | 1 | 3 | 14 | 6 | 13 |
| 9 | Parma AC | 8 | 4 | 1 | 3 | 10 | 9 | 13 |
| 10 | Sassuolo Calcio | 8 | 4 | 1 | 3 | 15 | 14 | 13 |
| 11 | Torino | 8 | 3 | 3 | 2 | 9 | 9 | 12 |
| 12 | Genoa CFC | 8 | 4 | 0 | 4 | 13 | 16 | 12 |
| 13 | US Cagliari | 8 | 2 | 3 | 3 | 6 | 9 | 9 |
| 14 | Spal | 8 | 3 | 0 | 5 | 6 | 10 | 9 |
| 15 | Udinese Calcio | 8 | 2 | 2 | 4 | 8 | 10 | 8 |
| 16 | Bologna FC | 8 | 2 | 1 | 5 | 4 | 10 | 7 |
| 17 | Atalanta BC | 8 | 1 | 3 | 4 | 9 | 11 | 6 |
| 18 | Empoli FC | 8 | 1 | 2 | 5 | 5 | 10 | 5 |
| 19 | AC Chievo Verona | 8 | 0 | 2 | 6 | 6 | 19 | 2 |
| 20 | Frosinone Calcio | 8 | 0 | 1 | 7 | 3 | 21 | 1 |
