| 2018-09-29 | AS Roma | 3-1 | SS Lazio |
| 2018-09-29 | FC Juventus | 3-1 | SSC Napoli |
| 2018-09-29 | FC Internazionale | 2-0 | US Cagliari |
| 2018-09-30 | Bologna FC | 2-1 | Udinese Calcio |
| 2018-09-30 | AC Chievo Verona | 0-1 | Torino |
| 2018-09-30 | AC Fiorentina | 2-0 | Atalanta BC |
| 2018-09-30 | Frosinone Calcio | 1-2 | Genoa CFC |
| 2018-09-30 | Parma AC | 1-0 | Empoli FC |
| 2018-09-30 | Sassuolo Calcio | 1-4 | AC Milan |
| 2018-10-01 | UC Sampdoria | 2-1 | Spal |
| Home | 7 |
| Draw | 0 |
| Away | 3 |
| Under | 4 |
| Over | 6 |
| Pos | Team | M. | W | D | L | GF | GA | Pts |
|---|---|---|---|---|---|---|---|---|
| 1 | FC Juventus | 7 | 7 | 0 | 0 | 16 | 5 | 21 |
| 2 | SSC Napoli | 7 | 5 | 0 | 2 | 13 | 10 | 15 |
| 3 | AC Fiorentina | 7 | 4 | 1 | 2 | 14 | 5 | 13 |
| 4 | FC Internazionale | 7 | 4 | 1 | 2 | 10 | 5 | 13 |
| 5 | Sassuolo Calcio | 7 | 4 | 1 | 2 | 15 | 12 | 13 |
| 6 | AC Milan | 7 | 3 | 3 | 1 | 14 | 10 | 12 |
| 7 | SS Lazio | 7 | 4 | 0 | 3 | 10 | 9 | 12 |
| 8 | Genoa CFC | 7 | 4 | 0 | 3 | 12 | 13 | 12 |
| 9 | UC Sampdoria | 7 | 3 | 2 | 2 | 11 | 4 | 11 |
| 10 | AS Roma | 7 | 3 | 2 | 2 | 14 | 10 | 11 |
| 11 | Parma AC | 7 | 3 | 1 | 3 | 7 | 8 | 10 |
| 12 | Torino | 7 | 2 | 3 | 2 | 6 | 7 | 9 |
| 13 | Spal | 7 | 3 | 0 | 4 | 5 | 8 | 9 |
| 14 | Udinese Calcio | 7 | 2 | 2 | 3 | 8 | 8 | 8 |
| 15 | Bologna FC | 7 | 2 | 1 | 4 | 4 | 8 | 7 |
| 16 | Atalanta BC | 7 | 1 | 3 | 3 | 9 | 10 | 6 |
| 17 | US Cagliari | 7 | 1 | 3 | 3 | 4 | 9 | 6 |
| 18 | Empoli FC | 7 | 1 | 2 | 4 | 5 | 8 | 5 |
| 19 | AC Chievo Verona | 7 | 0 | 2 | 5 | 5 | 16 | 2 |
| 20 | Frosinone Calcio | 7 | 0 | 1 | 6 | 1 | 18 | 1 |
