| 2018-09-25 | FC Internazionale | 2-1 | AC Fiorentina |
| 2018-09-26 | Udinese Calcio | 1-2 | SS Lazio |
| 2018-09-26 | Atalanta BC | 0-0 | Torino |
| 2018-09-26 | US Cagliari | 0-0 | UC Sampdoria |
| 2018-09-26 | Genoa CFC | 2-0 | AC Chievo Verona |
| 2018-09-26 | FC Juventus | 2-0 | Bologna FC |
| 2018-09-26 | SSC Napoli | 3-0 | Parma AC |
| 2018-09-26 | AS Roma | 4-0 | Frosinone Calcio |
| 2018-09-27 | Spal | 0-2 | Sassuolo Calcio |
| 2018-09-27 | Empoli FC | 1-1 | AC Milan |
| Home | 5 |
| Draw | 3 |
| Away | 2 |
| Under | 6 |
| Over | 4 |
| Pos | Team | M. | W | D | L | GF | GA | Pts |
|---|---|---|---|---|---|---|---|---|
| 1 | FC Juventus | 6 | 6 | 0 | 0 | 13 | 4 | 18 |
| 2 | SSC Napoli | 6 | 5 | 0 | 1 | 12 | 7 | 15 |
| 3 | Sassuolo Calcio | 6 | 4 | 1 | 1 | 14 | 8 | 13 |
| 4 | SS Lazio | 6 | 4 | 0 | 2 | 9 | 6 | 12 |
| 5 | AC Fiorentina | 6 | 3 | 1 | 2 | 12 | 5 | 10 |
| 6 | FC Internazionale | 6 | 3 | 1 | 2 | 8 | 5 | 10 |
| 7 | AC Milan | 6 | 2 | 3 | 1 | 10 | 9 | 9 |
| 8 | Spal | 6 | 3 | 0 | 3 | 4 | 6 | 9 |
| 9 | Genoa CFC | 6 | 3 | 0 | 3 | 10 | 12 | 9 |
| 10 | UC Sampdoria | 6 | 2 | 2 | 2 | 9 | 3 | 8 |
| 11 | AS Roma | 6 | 2 | 2 | 2 | 11 | 9 | 8 |
| 12 | Udinese Calcio | 6 | 2 | 2 | 2 | 7 | 6 | 8 |
| 13 | Parma AC | 6 | 2 | 1 | 3 | 6 | 8 | 7 |
| 14 | Atalanta BC | 6 | 1 | 3 | 2 | 9 | 8 | 6 |
| 15 | Torino | 6 | 1 | 3 | 2 | 5 | 7 | 6 |
| 16 | US Cagliari | 6 | 1 | 3 | 2 | 4 | 7 | 6 |
| 17 | Empoli FC | 6 | 1 | 2 | 3 | 5 | 7 | 5 |
| 18 | Bologna FC | 6 | 1 | 1 | 4 | 2 | 7 | 4 |
| 19 | AC Chievo Verona | 6 | 0 | 2 | 4 | 5 | 15 | 2 |
| 20 | Frosinone Calcio | 6 | 0 | 1 | 5 | 0 | 16 | 1 |
