| 2018-09-21 | Sassuolo Calcio | 3-1 | Empoli FC |
| 2018-09-22 | Parma AC | 2-0 | US Cagliari |
| 2018-09-22 | AC Fiorentina | 3-0 | Spal |
| 2018-09-22 | UC Sampdoria | 0-1 | FC Internazionale |
| 2018-09-23 | Torino | 1-3 | SSC Napoli |
| 2018-09-23 | Bologna FC | 2-0 | AS Roma |
| 2018-09-23 | AC Chievo Verona | 0-2 | Udinese Calcio |
| 2018-09-23 | SS Lazio | 4-1 | Genoa CFC |
| 2018-09-23 | AC Milan | 2-2 | Atalanta BC |
| 2018-09-23 | Frosinone Calcio | 0-2 | FC Juventus |
| Home | 5 |
| Draw | 1 |
| Away | 4 |
| Under | 5 |
| Over | 5 |
| Pos | Team | M. | W | D | L | GF | GA | Pts |
|---|---|---|---|---|---|---|---|---|
| 1 | FC Juventus | 5 | 5 | 0 | 0 | 11 | 4 | 15 |
| 2 | SSC Napoli | 5 | 4 | 0 | 1 | 9 | 7 | 12 |
| 3 | AC Fiorentina | 5 | 3 | 1 | 1 | 11 | 3 | 10 |
| 4 | Sassuolo Calcio | 5 | 3 | 1 | 1 | 12 | 8 | 10 |
| 5 | SS Lazio | 5 | 3 | 0 | 2 | 7 | 5 | 9 |
| 6 | Spal | 5 | 3 | 0 | 2 | 4 | 4 | 9 |
| 7 | Udinese Calcio | 5 | 2 | 2 | 1 | 6 | 4 | 8 |
| 8 | AC Milan | 5 | 2 | 2 | 1 | 9 | 8 | 8 |
| 9 | UC Sampdoria | 5 | 2 | 1 | 2 | 9 | 3 | 7 |
| 10 | FC Internazionale | 5 | 2 | 1 | 2 | 6 | 4 | 7 |
| 11 | Parma AC | 5 | 2 | 1 | 2 | 6 | 5 | 7 |
| 12 | Genoa CFC | 5 | 2 | 0 | 3 | 8 | 12 | 6 |
| 13 | Atalanta BC | 5 | 1 | 2 | 2 | 9 | 8 | 5 |
| 14 | Torino | 5 | 1 | 2 | 2 | 5 | 7 | 5 |
| 15 | AS Roma | 5 | 1 | 2 | 2 | 7 | 9 | 5 |
| 16 | US Cagliari | 5 | 1 | 2 | 2 | 4 | 7 | 5 |
| 17 | Empoli FC | 5 | 1 | 1 | 3 | 4 | 6 | 4 |
| 18 | Bologna FC | 5 | 1 | 1 | 3 | 2 | 5 | 4 |
| 19 | AC Chievo Verona | 5 | 0 | 2 | 3 | 5 | 13 | 2 |
| 20 | Frosinone Calcio | 5 | 0 | 1 | 4 | 0 | 12 | 1 |
