| 2018-09-15 | FC Internazionale | 0-1 | Parma AC |
| 2018-09-15 | SSC Napoli | 1-0 | AC Fiorentina |
| 2018-09-15 | Frosinone Calcio | 0-5 | UC Sampdoria |
| 2018-09-16 | AS Roma | 2-2 | AC Chievo Verona |
| 2018-09-16 | Genoa CFC | 1-0 | Bologna FC |
| 2018-09-16 | FC Juventus | 2-1 | Sassuolo Calcio |
| 2018-09-16 | Udinese Calcio | 1-1 | Torino |
| 2018-09-16 | Empoli FC | 0-1 | SS Lazio |
| 2018-09-16 | US Cagliari | 1-1 | AC Milan |
| 2018-09-17 | Spal | 2-0 | Atalanta BC |
| Home | 4 |
| Draw | 3 |
| Away | 3 |
| Under | 7 |
| Over | 3 |
| Pos | Team | M. | W | D | L | GF | GA | Pts |
|---|---|---|---|---|---|---|---|---|
| 1 | FC Juventus | 4 | 4 | 0 | 0 | 9 | 4 | 12 |
| 2 | Spal | 4 | 3 | 0 | 1 | 4 | 1 | 9 |
| 3 | SSC Napoli | 4 | 3 | 0 | 1 | 6 | 6 | 9 |
| 4 | UC Sampdoria | 4 | 2 | 1 | 1 | 9 | 2 | 7 |
| 5 | AC Fiorentina | 4 | 2 | 1 | 1 | 8 | 3 | 7 |
| 6 | Sassuolo Calcio | 4 | 2 | 1 | 1 | 9 | 7 | 7 |
| 7 | AC Milan | 4 | 2 | 1 | 1 | 7 | 6 | 7 |
| 8 | SS Lazio | 4 | 2 | 0 | 2 | 3 | 4 | 6 |
| 9 | Genoa CFC | 4 | 2 | 0 | 2 | 7 | 8 | 6 |
| 10 | Torino | 4 | 1 | 2 | 1 | 4 | 4 | 5 |
| 11 | AS Roma | 4 | 1 | 2 | 1 | 7 | 7 | 5 |
| 12 | Udinese Calcio | 4 | 1 | 2 | 1 | 4 | 4 | 5 |
| 13 | US Cagliari | 4 | 1 | 2 | 1 | 4 | 5 | 5 |
| 14 | FC Internazionale | 4 | 1 | 1 | 2 | 5 | 4 | 4 |
| 15 | Atalanta BC | 4 | 1 | 1 | 2 | 7 | 6 | 4 |
| 16 | Empoli FC | 4 | 1 | 1 | 2 | 3 | 3 | 4 |
| 17 | Parma AC | 4 | 1 | 1 | 2 | 4 | 5 | 4 |
| 18 | AC Chievo Verona | 4 | 0 | 2 | 2 | 5 | 11 | 2 |
| 19 | Bologna FC | 4 | 0 | 1 | 3 | 0 | 5 | 1 |
| 20 | Frosinone Calcio | 4 | 0 | 1 | 3 | 0 | 10 | 1 |
