| 2018-11-09 | Frosinone Calcio | 1-1 | AC Fiorentina |
| 2018-11-10 | Torino | 1-2 | Parma AC |
| 2018-11-10 | Spal | 2-2 | US Cagliari |
| 2018-11-10 | Genoa CFC | 1-2 | SSC Napoli |
| 2018-11-11 | Atalanta BC | 4-1 | FC Internazionale |
| 2018-11-11 | AC Chievo Verona | 2-2 | Bologna FC |
| 2018-11-11 | Empoli FC | 2-1 | Udinese Calcio |
| 2018-11-11 | AS Roma | 4-1 | UC Sampdoria |
| 2018-11-11 | Sassuolo Calcio | 1-1 | SS Lazio |
| 2018-11-11 | AC Milan | 0-2 | FC Juventus |
| Home | 3 |
| Draw | 4 |
| Away | 3 |
| Under | 3 |
| Over | 7 |
| Pos | Team | M. | W | D | L | GF | GA | Pts |
|---|---|---|---|---|---|---|---|---|
| 1 | FC Juventus | 12 | 11 | 1 | 0 | 26 | 8 | 34 |
| 2 | SSC Napoli | 12 | 9 | 1 | 2 | 26 | 13 | 28 |
| 3 | FC Internazionale | 12 | 8 | 1 | 3 | 22 | 10 | 25 |
| 4 | SS Lazio | 12 | 7 | 1 | 4 | 18 | 14 | 22 |
| 5 | AC Milan | 12 | 6 | 3 | 3 | 21 | 16 | 21 |
| 6 | AS Roma | 12 | 5 | 4 | 3 | 22 | 15 | 19 |
| 7 | Sassuolo Calcio | 12 | 5 | 4 | 3 | 20 | 17 | 19 |
| 8 | Atalanta BC | 12 | 5 | 3 | 4 | 23 | 14 | 18 |
| 9 | AC Fiorentina | 12 | 4 | 5 | 3 | 18 | 10 | 17 |
| 10 | Torino | 12 | 4 | 5 | 3 | 17 | 15 | 17 |
| 11 | Parma AC | 12 | 5 | 2 | 5 | 12 | 15 | 17 |
| 12 | UC Sampdoria | 12 | 4 | 3 | 5 | 16 | 15 | 15 |
| 13 | US Cagliari | 12 | 3 | 5 | 4 | 12 | 16 | 14 |
| 14 | Genoa CFC | 12 | 4 | 2 | 6 | 17 | 26 | 14 |
| 15 | Spal | 12 | 4 | 1 | 7 | 11 | 19 | 13 |
| 16 | Bologna FC | 12 | 2 | 4 | 6 | 11 | 18 | 10 |
| 17 | Udinese Calcio | 12 | 2 | 3 | 7 | 11 | 18 | 9 |
| 18 | Empoli FC | 12 | 2 | 3 | 7 | 12 | 21 | 9 |
| 19 | Frosinone Calcio | 12 | 1 | 4 | 7 | 10 | 25 | 7 |
| 20 | AC Chievo Verona | 12 | 0 | 3 | 9 | 10 | 30 | 3 |
